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稀土芦丁配合物的合成、表征及抗肿瘤活性研究
Study on Synthesis,Characterization and Anti-Tumor Activity of Rare Earth-Rutin Complex
【摘要】 合成了稀土离子Tb3+的芦丁配合物,通过元素分析、核磁共振氢谱、摩尔电导、红外光谱、紫外光谱,确定了配合物的组成和结构,结果表明,配合物的组成为Na5TbLCl7.6H2O(L=C27H29O16)。同时采用噻唑蓝还原法(MTT比色法)测定了配体及配合物对HepG2肝癌细胞株的抗肿瘤活性,实验结果表明,配合物对HepG2肝癌细胞的抗肿瘤活性强于配体。
【Abstract】 The complex of rare earth element Tb with rutin was synthesized and characterized by elemental analysis,1H NMR,molar conductance,IR and UV spectra.The formula of the complex,Na5TbLCl7·6H2O(L=C27H29O16) was given.MTT colorimetric assay was used to detect the anti-tumor activity of the ligand and the complex on human hepatocarcinoma cell line HepG2.The anti-tumor activity of the complex was stronger than that of the ligand.
【关键词】 芦丁;
稀土金属;
配合物;
噻唑蓝比色法;
抗肿瘤活性;
【Key words】 Rutin; Rare Earth Metal; Complex; MTT Colorimetric Assay; Anti-Tumor Activity;
【Key words】 Rutin; Rare Earth Metal; Complex; MTT Colorimetric Assay; Anti-Tumor Activity;
【基金】 江西省教育厅2007年科技项目(2007209)
- 【文献出处】 光谱实验室 ,Chinese Journal of Spectroscopy Laboratory , 编辑部邮箱 ,2011年02期
- 【分类号】R284;R285;O621.2
- 【被引频次】17
- 【下载频次】422