【摘要】 目的探讨骨的孤立性浆细胞瘤的临床病理特征及诊断方法。方法 收集和复习本院1996年1月至2009年12月病理确诊为骨的孤立性浆细胞瘤6例临床资料,通过对其临床特征、影像学表现、血尿检测、病理常规HE染色及免疫组化染色等进行分析,并复习相关文献。结果 6例骨的孤立性浆细胞瘤均为单一区域骨骼破坏,好发于红髓丰富的部位,分别为肋骨2例、颅骨2例、胸椎1例、股骨干1例;男性比女性常见,男女之比为2∶1。临床表现为单骨部位疼痛,无贫血、高钙血症和肾功能损害,尿Bence-Jones蛋白阴性;免疫组化表达CD38和/或CD138,单克隆表达轻链球蛋白Kappa 2例、Lambda 4例。结论 骨的孤立性浆细胞瘤较为罕见,确诊需综合多方面情况,且首先应排除骨多发性骨髓瘤。更多还原

【Abstract】 Objective To investigate the clinical pathologic feature and the diagnosis method about the solitary plasmacytoma of bone.Methods We collected and reviewed the clinical information of 6 cases of the final pathologic diagnosis solitary plasmacyoma of bone who were treated in our hospital from January,1966 to December,2009,through the clinical feature,imageologic appearance,the detection of blood and urine,pathologic routine HE staining and immunohistochemical staining to analyze,and reviewed pertinent literature.Results All the 6 cases with the solitary plasmacytoma of bone were skeletal destruction of single region,especially frequent in the location of abundance splenic pulp,2 lesions involved the costal bone,2 leisons cranium,1 leison thoracic vertebra and 1 leison involved shaft of femur,respectively,and more common in male than that in female(the ratio of male to female was 2∶1).The clinical situations were the pain of single bone location,no anaemia,hypercalcinemia and the damage of renal function,negative urine Bence-Jones proteins.Immunohistochemical expressions were CD38 and(or)CD138,and monoclonal expreesions were light chain globulin κ(2 cases) and λ(4 cases).Conclusion The solitary plasmacytoma of bone rarely occured,final diagosis is demanded to combine varietal information,and should excluse the multiple myeloma.更多还原