【摘要】 氧化应激在中枢神经系统疾病的发生发展中起了关键作用。最近,氢气被证实在体内具有选择性的抗氧化作用。它能专一性清除毒性自由基:羟自由基(.OH)和过氧化亚硝酸盐(ONOO-),而保存其他自由基低活性生理功能。在神经系统中,氢气被证实具有抗氧化、抗炎症、抗凋亡的机制,在脑缺血缺氧损伤、神经变性、脊髓损伤等疾病中被证实具有神经保护作用。至此,氢气作为一种新型抗氧化剂为神经系统疾病的临床防治提供了崭新的方法。更多还原

【Abstract】 Oxidative stress plays a pivotal role in the pathogenesis of varied nervous system diseases.Recent studies have demonstrated that hydrogen has selective antioxidative effect.It selectively reduces the hydroxyl radical(·OH) and peroxynitrite(ONOO-),the most cytotoxic of reactive oxygen species(ROS);however,it does not affect other ROS,which play important physiological roles at low concentrations.A large body of experimental studies has proved that hydrogen,through anti-oxidation,anti-inflammatory and inhibiting apoptosis,has a significant therapeutic effect in various neurological diseases,such as ischemia,hypoxia,degeneration and spinal cord contusion.It provides us with a new clinical method for the prevention and treatment of neurological diseases.更多还原