【摘要】 目的:研究伴3q异常的急性髓系白血病(acute myeloid leukemia,AML)的临床及实验室特征。方法:采用R带常规显带技术进行染色体检查,对657例AML患者的核型进行分析。结果:在657例AML患者中检出3q异常患者24例,检出率3.7%;在24例患者中,涉及3q21或3q26异常18例(75.0%),其中3q21q26异常11例(45.8%),包括9例t(3;3)及2例inv(3);其余伴3q异常的6例患者,2例为t(1;3),t(2;3)、t(3;7)、t(3;11)及t(3;14)各1例。11例3q21q26异常的AML患者,其中3例从骨髓增生异常综合征转化而来,10例患者血小板正常或增高,骨髓形态学为巨核细胞异常增殖。而在其余7例伴3q21或3q26异常的患者中均未见有血小板增高及骨髓巨核细胞的增殖。24例涉及3q异常的AML患者化疗疗效差,仅4例患者获得短期缓解,中位生存仅6.7个月。结论:AML的3q异常以3q21q26最为常见,且涉及3q异常的AML患者,无论是3q21q26还是其他异常的患者治疗效果差,预后不良。更多还原

【Abstract】 Objective: To investigate the clinical characteristics of acute myeloid leukemia patients with 3q abnormalities.Methods: Conventional cytogenetic analysis of R-banding was used to detect the abnormalities of 3q in 657 patients with acute myeloid leukemia(AML).Results: Twenty-four(3.7%) out of 657 patients had abnormalities of 3q,of which 3q21 or 3q26 were involved in 18 cases(75.0%);3q21q26 abnormalities were harbored in 11 patients(45.8%),including 9 of t(3;3) and 2 cases of inv(3),of which 3 cases progressed from MDS.Ten patients presented with normal or elevated platelets and their bone marrow morphologies showed abnormal and striking proliferation of megakaryocytes.While in other 7 patients with 3q21 or 3q26,no one presented with high platelets and megakaryocytes.All 24 patients with 3q abnormalities received chemotherapies and only 4 patients achieved short-term remission with a median survival time of 6.7 months.Conclusions: 3q21q26 anomaly is the most common karyotype in acute myeloid patients with 3q abnormalities.The patients with 3q anomaly had extremely poorer treatment outcome and prognosis.更多还原