【摘要】 目的:探讨脂代谢异常与子痫前期发生、发展的关系。方法:测定115例子痫前期患者(其中轻度子痫前期56例,重度子痫前期59例)与50例正常孕妇血浆中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白(Apo-A、Apo-B)、Lp(a)水平与血清游离脂肪酸(FFA)水平,并进行对比研究;测定子痫前期患者24h尿蛋白定量值。结果:轻度子痫前期组(轻度PE组)和重度子痫前期组(重度PE组)中的TC、TG、LDL、Apo-B、Lp(a)、FFA水平随着病情的进展逐渐升高,重度子痫前期组中TC、TG、Apo-B与对照组相比差异均有统计学意义(P<0.05),轻度PE组和重度PE组中的LDL、Lp(a)、FFA水平与对照组相比差异有统计学意义(P<0.05),轻度PE组和重度PE组中的HDL、ApoA1水平则随着病情进展逐渐下降,重度PE组中的HDL、ApoA1水平与对照组相比差异有统计学意义(P<0.05)。结论:子痫前期患者体内脂质代谢发生明显异常,并伴有氧化应激增强和毒性产物增加,造成血管内皮细胞损伤。脂代谢异常与该病的发生、发展密切相关。更多还原

【Abstract】 Objective:To explore the relationship between abnormal lipid metabolism and occurrence,development of preeclampsia.Methods:The levels of total cholesterol (TC),triglyceride (TG),high density lipoprotein (HDL),low density lipoprotein (LDL),apo-A,apo-B and Lp(a) in plasma and level of free fatty acid in serum in 115 cases with preeclampsia and 50 normal pregnant women were detected and compared;24 hours urinary protein excretion was detected in cases with preeclampsia.Results:The levels of TC,TG,LDL,Apo-B,Lp(a) and FFA in mild preeclampsia group and severe preeclampsia group increased gradually with the aggravation of disease;there was significant difference in levels of TC,TG and Apo-B between severe preeclampsia group and control group (P<0.05).There was significant difference in levels of LDL,Lp(a) and FFA between mild preeclampsia group,severe preeclampsia group and control group (P<0.05).The levels of HDL and ApoA1 in mild preeclampsia group and severe preeclampsia group decreased gradually with the aggravation of disease;there was significant difference in levels of HDL and ApoA1 between severe preeclampsia group and control group (P<0.05).Conclusion:Obvious abnormality of lipid metabolism exists in patients with preeclampsia,combined with enhancement of oxidative stress and increase of toxic products,which may harm the vascular endothelial cells;abnormal lipid metabolism is related to occurrence and development of preeclampsia closely.更多还原