【摘要】 目的:探讨HPV感染阴性的子宫颈鳞状细胞癌(CSC)中PCNA、PMAPK、MMP-9、β-integrin的表达及其与侵袭、转移的关系。方法:采用免疫组织化学SP法检测经PCR方法筛选出17例HPV感染阴性CSC及20例HPV感染阳性CSC的标本中PCNA、PMAPK、MMP-9、β-integrin的表达;应用图像分析软件分别对4种抗体的表达进行分析。结果:HPV阴性CSC组PCNA、PMAPK、MMP-9、β-integrin的表达水平与HPV阳性CSC组的表达水平差异无统计学意义(P>0.05)。结论:HPV阴性CSC和HPV阳性CSC的生物学特点相似,均具有较强的侵袭、转移特性,说明CSC的生物学特性及预后与HPV感染无直接相关性。更多还原

【Abstract】 Objective:To investigate the expression of PCNA,PMAPK,MMP-9 and β-integrins in HPV-negative cervical squamous cell carcinomas(CSC) and the relation with invasion and metastasis.Methods:SP immunohistochemistry staining was used to detected the expressions of PCNA,PMAPK,MMP-9,β-integrins in 17 cases of HPV-negative CSC and 20 cases of HPV-positive CSC which screened out by the PCR detection.The expressions were analyzed by the image analytic software.Results:The levels of the expressions of PCNA,PMAPK,MMP-9,β-integrins of HPV-negective CSC had no significant difference between of HPV-positive CSC(P>0.05)Conclusion:The biological characteristics of HPV-negective CSC are similar with HPV-positive CSC,both have stong invasion and metastasis,which come to the conclusion that the Bioogical characteristics and prognosis of cervical squamous cell carcinomas are not related to the infection of HPV.更多还原