【摘要】 目的:探讨初级渗透泵控释片的药物递释机制。方法:在已制备秋水仙碱初级渗透泵片表面用微型钻头打单侧孔,用HPLC测定渗透泵片中秋水仙碱溶出度来考察释药孔径大小和释药介质渗透压对其体外释药行为的影响。结果:该渗透泵片呈现较好的零级释放特征(r=0.9902),其体外释药速率与介质渗透压呈反比、受释药孔径影响较小但在一定范围内呈正相关。药物主要经由释药小孔释出膜外。结论:渗透压在其药物递释机制中占主导地位(62.58%),其次为扩散释药。更多还原

【Abstract】 AIM: To investigate the drug delivery mechanism of elementary osmotic-pump tablets with colchicine as the model drug.METHODS: The colchicine osmotic-pump tablets prepared was carried out to punch onesidedly with microbit on the tablet surface.HPLC was used to measure the dissolution of colchicine to observe the effect of osmotic pressure of test media and orifice size on the release rate of colchicine.RESULTS: The experimental results showed that the release rate of colchicine decreased as the osmotic pressure increased and as the orifice size lessened,but represented the positive correlation in certain range.Release of colchicine was mainly concerned with orifice and not with coating membrane.Osmotic-pump tablet was characteristic of zero-order release.CONCLUSION: Osmotic pressure plays a key role in releasing colchocine(62.58% ),diffusion is secondary one.更多还原