【摘要】 目的探讨实验兔脑弥漫性轴索损伤磁共振波谱(MRS)表现及其应用价值。方法实验兔32只,复制创伤性脑损伤的动物模型,分别在损伤前及损伤后4、8、24和48h行MRS检查,观察NAA/Cr、Cho/Cr的变化,并与病理对照。结果打击后4h即可见到创伤性脑损伤的病理表现,MRS示NAA/Cr 4h显著下降,8h轻度上升,而24～48h变化无显著性差异,而Cho/Cr损伤前后变化无显著差异。结论 MRS能无创性定量监测脑外伤脑组织生化代谢改变,为早期诊断、治疗和预后评估提供理论依据。更多还原

【Abstract】 Objective To investigate proton magnetic resonance spectroscopy (’H-MRS) findings and applied value on diffuse axonal injury of rabbit’s brain. Methods Traumatic brain injury model was established in 32 rabbits, and MRS was performed 4, 8, 24 and 48 hours before trauma and after trauma. NAA/Cr、Cho/Cr changes were calculated with pathological findings compared respectively. Results Pathological findings of traumatic brain injuries showed 4h after injury occurrence, the ratio of NAA/Cr decreased dramatically 4 hours after trauma, followed by a mild recovery within 8 hours. However, no significant change happened from 24h to 48h, with no significant deviation before and after Cho/Cr trauma. Conclusion MRS can be used to non-invasively monitor the metabolic changes and provide theoretical data for early diagnosis, therapy and prognostic evaluation.更多还原