【摘要】 目的探讨甲状腺乳头状癌(PTC)超声造影血流灌注定量参数与肿瘤微血管密度的相关性。方法 52例甲状腺乳头状癌患者术前行超声造影检查,利用时间-强度曲线进行定量分析,得出甲状腺乳头状癌及癌旁组织的达峰时间(TTP)、峰值强度(P)I,与术后病理免疫组织化学染色的微血管密度(MVD)进行相关性分析。结果 52例甲状腺乳头状癌及癌旁组织的TTP平均值分别为(10.29±4.15)s及(21.93±6.01)s;PI平均值分别为(37.02±5.96)dB及(18.34±4.16)dB,MVD平均值分别为51.42±9.17及22.31±6.97。甲状腺乳头状癌术前TTP与术后MVD呈负相关(r=-0.807,P<0.05),PI与MVD呈正相关(r=0.818,P<0.05)。结论甲状腺乳头状癌超声造影定量参数TTP、PI与MVD的表达有良好的相关性,可用于术前间接评价肿瘤的血管生成,为甲状腺乳头状癌的临床诊治,预测预后提供帮助。更多还原

【Abstract】 Objective To investigate the correlation between quantitation parameters of blood perfusion with contrast-enhanced ultrasound(CEUS) and microvessel density(MVD) in papillary thyroid carcinoma(PTC). Methods CEUS was examined before operation in 52 patients with PTC. Time-intensity curves(TIC) in 52 cases with PTC were analyzed to get the time to peak(TTP) and peak intensity(PI) of PTC and tissue around PTC. These parameters were analyzed correlatively with MVD counted with immunocytochemistry. Results The mean TTP of PTC and tissue around PTC were (10.29±4.15)s and (21.93±6.01)s,the mean PI of PTC and tissue around PTC were (37.02±5.96) dB and (18.34±4.16)dB,the mean MVD of PTC and tissue around PTC were 51.42±9.17 and 22.31±6.97.The TTP before operation correlated inversely to MVD (r=-0.807,P<0.05)of histological section after operation. The PI before operation was correlated positively to MVD (r =0.818,P <0.05)of histological section after operation. Conclusion The quantitative parameters of blood perfusion,TTP and PI calculated from CEUS were correlated to MVD. CEUS may be used to evaluated the angiogenesis in PTC before operation,and is helpful for clinical diagnosis,treatment,and prediction of prognosis of PTC.更多还原