【摘要】 [目的]了解深圳地区学龄前儿童乙肝病毒感染状况及疫苗接种效果,为乙型肝炎的防治提供依据。[方法]采用ELISA方法检测2955例学龄前儿童乙肝血清学指标(HBV-M)。[结果]深圳地区学龄前儿童乙肝血清学五项指标阳性率分别为0.95%、76.45%、0.74%、0.61%和1.25%;各指标阳性率在男女之间无性别差异;HBV-M全阴儿童668例,占22.61%,HBV-M阳性模式共检出7种,其中"大三阳"(HBsAg+HBeAg+HBcAb)22例(0.74%),"小三阳"(HBsAg+HBeAb+HBcAb)5例(0.17%),"大二阳"(HBsAg+HBeAg)1例(0.03%),HBsAb单独阳性2236例(75.67%),HBsAb+HBeAb5例(0.17%),HBsAb+HBeAb+HBcAb6例(0.20%),HBsAb+HBcAb12例(0.41%)。[结论]深圳地区流动人口多,疾病防治工作难度大,学龄前儿童乙肝病毒感染状况较强制性计划免疫前有很大改善,疫苗接种有一定效果,但仍需从多个因素优化条件,进一步提高疫苗效果。更多还原

【Abstract】 [Objective] To analyze the infection of HBV and the effect of HBV vaccine in children aged from half a year to 6 years,and to provide data for HBV prevention and control in Shenzhen.[Methods] HBV-M among 2 955 children’s serum was detected by ELISA.[Results] The positive ratio of HBsAg,HBsAb,HBeAg,HBeAb and HBcAb were 0.95%,76.45%,0.74%,0.61% and 1.25%,respectively;There was no significant difference between the positive ratio of boys and girls.HBV-M among 668(22.61%) children was negative completely.There were 7 positive combined mode of HBV-M as a whole,including 22(0.74%) cases with ’HBsAg+HBeAg+HBcAb’,5(0.17%) cases with ’HBsAg+HBeAb+HBcAb’,1(0.03%) case with ’HBsAg+HBeAg’,2236(75.67%) cases with HBsAb positive alone,5(0.17%) cases with ’HBsAb+ HBeAb’,6(0.20%) cases with ’HBsAb+ HBeAb+ HBcAb’ and 12(0.41%) cases with ’HBsAb + HBcAb’.[Conclusion] For so many floating population,it is difficult to prevent and control the Hepatitis B in Shenzhen.After compulsive injection of HBV vaccine,the situation of HBV infection becomes better than before,but some measures must be taken to improve the effect of HBV vaccine.更多还原