【摘要】 [目的]初步探讨新疆某市吸毒人群血清KSHV感染特点。[方法]ELISA法检测血清KSHV潜伏期LANA1、溶解期ORF65、K8.1抗原抗体;利用χ2检验、Logistic回归分析数据。[结果]共检测223份吸毒者血清,吸毒人群主要以注射吸毒者为主(185/223,83%),KSHV阳性64份,KSHV血清阳性率为28.7%。统计分析显示,年龄、职业、文化程度、婚姻状况以及吸毒年限与KSHV血清阳性率无关;吸毒方式、HIV-1感染与吸毒人群KSHV血清阳性率有相关性,是KSHV感染的危险因素,HIV-1感染对KSHV感染的OR为3.310(95%CI为1.116～9.814)。[结论]KSHV普遍存在于该地区吸毒人群中,静脉注射吸毒、HIV-1可能是KSHV血清阳性率的独立危险因素,静脉注射吸毒可能是该人群KSHV传播的主要途径。更多还原

【Abstract】 [Objective] To research primary features of Kaposi’s Sarcoma-associated Herpesvirus infection in drug users in a city of Xinjiang. [Methods] Antibodies of KSHV latent antigen ORF73,lytic antigens K8.1 and ORF65 were measured by ELISA. Chi-square test and Logistic regression model were performed to analyze the data. [Results] In this study,intravenous drug users were predominant in all the drug users (185/223,83%),and 64 out of 223 sera samples (28.7%) were KSHV positive. There was no differences among age,occupation,education levels,and marriage statuses. By Logistic regression analysis,we found that the way of drug abuse and HIV-1 infection were associated with KSHV seroprevalence,HIV-1 positive OR=3.310 (95%CI:1.116-9.814),intravenous drug abuse and HIV-1 infection were risk factors. [Conclusion] KSHV is common among these drug users. Intravenous drug abuse and HIV-1 positive status are independent risk factors for KSHV seroprevalence,and it suggests that intravenous drug abuse may be a specific route of transmission in this population.更多还原