【摘要】 目的:研究三味舒郁方抗抑郁的择时用药。方法:通过小鼠悬尾实验、强迫游泳实验以及小鼠脑单胺氧化酶活性的测定,观察三味舒郁方在不同给药时间的抗抑郁作用。结果:三味舒郁方能明显缩短小鼠悬尾不动时间和强迫游泳不动时间,降低脑单胺氧化酶的活性(P<0.05或P<0.01)。结论:三味舒郁方有明显的抗抑郁作用,且在晨间给药的抗抑郁强度大于夕间给药。更多还原

【Abstract】 Objective:To investigate the antidepressant effects of Sanweishuyu recipe by chrono-medication.Methods:The antidepressant effects of Sanweishuyu recipe were measured concerning chrono-medication by the two behavioral despair experiments of mouse tail suspension and forced swimming test and determination of the monoamine oxidase(MAO)activity in the brain of mice.Results:Sanweishuyu recipe significantly reduced the duration of immobility of tail suspension and forced swimming and the activity of MAO as well(P<0.05 or P<0.01).Conclusion:Sanweishuyu recipe can evidently be effective in anti-depression,and it functions better in morning hours than at dusk.更多还原