【摘要】 目的:观察伴冠心病(CHD)的老年原发性高血压(EH)患者与单纯老年EH患者血清单核细胞趋化蛋白-1(MCP-1)、白细胞介素-6(IL-6)含量的变化,并探讨其临床意义。方法:分别测定42例单纯EH患者(单纯EH组)、53例EH伴CHD患者(EH+CHD组)及30例老年健康体检者(健康对照组)MCP-1、IL-6的含量,同时探讨MCP-1、IL-6与EH、CHD的相关性。结果:单纯EH组、EH+CHD组患者血清MCP-1、IL-6含量均明显高于健康对照组(P<0.01);EH+CHD组血清MCP-1、IL-6高于单纯EH组(P<0.01)。所有EH患者血清IL-6、MCP-1分别与收缩压(SBP)成正相关(r=0.258,P<0.05;r=0.371,P<0.01)。Logistic回归分析提示MCP-1、IL-6与EH患者并发CHD相关。结论:MCP-1、IL-6分别与SBP水平成正相关,并与EH患者发生冠状动脉粥样硬化相关。更多还原

【Abstract】 Objective To observe the expressions and clinical significances of serum monocyte chemoattr-actant protein-1 (MCP-1) and interleukin-6 (IL-6) in elderly essential hypertensive (EH) patients with or without coronary heart diseases. Methods Serum contents of MCP-1 and IL-6 were determined in 42 EH patients, 53 EH patients with CHD,and 30 healthy controls,and the correlations between IL-6,MCP-1 and EH,CHD were investigated. Results Compared with healthy controls, MCP-1 and IL-6 were significantly increased in EH patients and EH patients with CHD (P < 0.01),and those were significantly higher in EH patients with CHD than those in EH patients(P < 0.01). IL-6 and MCP-1 were positively correlated with systolic blood pressure (SBP) (r = 0.258,P < 0.05;r = 0.371,P < 0.01). Logistic regression analysis shown that MCP-1 and IL-6 were related to CHD in EH patients. Conclusions Both MCP-1 and IL-6 were positively correlated with SBP, and were related with coronary atherosclerosis in EH patients.更多还原