【摘要】 分泌系统对于具有特殊细胞被膜结构的分枝杆菌,尤其是致病性分枝杆菌的存活和毒力非常重要.不少重要的致病因子或存活因子都通过特定的分泌系统进入环境,包括宿主体内.本文从分泌系统的基因、结构组成、分泌底物、转运机制及其与致病菌毒力的关系等几个方面介绍了分枝杆菌(mycobacteria)通用型分泌系统(general secretion pathway,SecA1)、替代型分泌系统(accessory Sec system,SecA2)、双精氨酸分泌系统(twin-arginine translocation,Tat)和Ⅶ型分泌系统(typeⅦsecretion systems,T7S system or ESX)4种分泌系统,并重点分析了Tat分泌系统.这些知识有利于从分泌系统及其底物的角度揭示结核分枝杆菌等胞内致病菌存活和逃避宿主免疫的机理,将为研发新的结核病控制措施提供依据.更多还原

【Abstract】 Secretion systems are very important for the survival and virulence of mycobacteria,a group of bacteria with unique cell-envelope structure,especially pathogenic ones. Most of essential virulence factors or survival factors are exported to the extracellular surroundings including the host cytoplasm by the secretion systems. Components,substrates,translocation mechanisms and relation to the virulence of the twin-arginine translocation ( Tat) pathway,the general secretion pathway ( SecA1),the accessory Sec system (SecA2) and the type Ⅶ secretion systems (T7S system or ESX-1) were summarized in this paper. The emphasis is TAT system. This review summarizes the recent progress on the tactics that intracellular pathogen exemplified by M. tuberculosis manipulates the host immune response to thrive and facilitate novel TB countermeasures development.更多还原