【摘要】 目的探讨预防肺移植术后曲霉菌感染的药物疗效。方法 2003年7月～2010年4月,为38例患者实行肺移植手术,应用伊曲康唑,氟康唑在预防肺移植术后曲霉菌感染的临床效果和在卫生经济学方面来比较和评价。结果应用伊曲康唑比应用氟康唑在预防肺移植术后曲霉菌感染的发生率明显降低(P=0.002)。并且可以减少肺移植术后患者并发曲霉感染的风险,降低相应的治疗费用,有效的节约社会医疗资源。结论应用伊曲康唑和二性霉素B雾化在对肺移植术后的早期曲霉菌感染的预防和治疗中是相对有效的。更多还原

【Abstract】 Objective To investigate the prophylactic regimen on aspergillosis in lung allograft recipients.Methods From July 2003 to September 2010,we performed 38 cases of lung transplantation successfully.The recipients received either Itraconazole-based or Fluconazole-based regimen for preventing aspergillosis.We compared these two regimens on the clinical effect of prevention and on medical economics.Results The recipients in the group of Itraconazole-based regimen had a much lower morbidity of aspergillosis than those using Fluconazole-based regimen(P = 0.002).The Itraconazole-based regimen decreased the risk of aspergillosis in lung allograft recipients as well as medical expense.Conclusion Compared to Fluconazole-based regimen,the regimen of Itraconazole combined with aerosolized amphotericin B was more effective in the prevention and cure of aspergillosis on the early stage of post-lung transplantation.更多还原