【摘要】 目的探讨宫内慢性缺氧对子代大鼠血压的影响。方法 SD大鼠孕鼠于妊娠第7~21天,每日置于氧气浓度为10%±1%的低压氧舱3 h,待分娩后观测其子代大鼠体重、主要脏器重量及血压的变化。结果宫内缺氧组仔鼠出生后第1天体重显著低于对照组(P<0.01),但出生后第20天体重与对照组无显著性差异;宫内缺氧组仔鼠肝脏于出生后第1、20天以及雄性仔鼠肾脏于出生后3月、7月的重量显著低于对照组(P<0.05);5月龄、7月龄宫内缺氧组子代雄性大鼠血压均比同性别对照组显著升高(P<0.05),且呈现随年龄增长而逐渐加重趋势,但宫内缺氧子代雌性大鼠血压与对照组相比无显著性差异。结论慢性宫内缺氧可能是引起大鼠肝、肾、血管组织程序控制的应激因素之一。它可诱发子代雄性大鼠血压升高,呈现性别依赖现象,并随年龄增长有逐渐加重倾向。更多还原

【Abstract】 Aim To investigate the effects of fetal intrauterine chromic hypoxia on the blood pressure of offspring rats. Methods Pregnant Sprague-Dawley rats were subjected to hypoxia for 3 hours in low pressure cabin with an oxygen concentration of 10%±1% from day 7 to day 21 of pregnancy.The body weight,organs weight and blood pressure were determined in the offspring rats. Results Fetal hypoxia offspring growth were retarded at birth(P<0.01) but had similar weight to controls at 20 days of age.There were significant declines in liver weight of offspring at birth and 20 days of age,and significant decreases in kidney weight of male offspring at 3 and 7 months of age(all P<0.05).Systolic blood pressures were significantly elevated in male hypoxia offspring rats at 5 and 7 months of age as compared with controls(all P<0.05),and aggravated with age.But it was not significantly different from controls in female hypoxia offspring rats. Conclusion Intrauterine chromic hypoxia may be a stress factor for fetal programming in rat liver,kidney and vascular tissues. It can induce the increased blood pressure in the male offspring rats,which aggravated with age and displayed a gender related character.更多还原