【摘要】 目的:对比观察羊膜移植联合低浓度丝裂霉素C在治疗原发性青光眼中的临床效果。方法:对33例48眼原发性急性闭角型青光眼患者分为两组,联合组和单纯组,联合组采取低浓度丝裂霉素联合羊膜移植、小梁切除术治疗,单纯组用较高浓度丝裂霉素、小梁切除术,术后观察眼压、视力、滤过泡及并发症。结果:联合组视力提高较单纯组视力提高明显,且有显著性差异(P<0.05);术后3个月随访时,单纯组眼压控制较联合组低,且差异有显著性(P<0.05);联合组功能性滤过泡(87.5%)较单纯组(70.83%)高,并发症较单纯组少。结论:羊膜移植联合低浓度丝裂霉素治疗原发性青光眼具有眼压控制满意,并发症少等优点。更多还原

【Abstract】 Objective:To study the clinical effect of trabeculectomy combined with amniotic membrane transplation and mitomycin C in primary glaucoma.Methods:Thirty-three cases (48 eyes)with primary glaucoma were randomized into two groups:thecombined group underwent trabeculectomy combined with amniotic membrane transplation and mitomycin;the single group with traditional trabeculectomy and mitomycin C.The intraocular pressuer (IOP),visual acuity,filtering blebs were measured and compared between the two groups after operation.Results:The decrease of visual acuity was seen in 10 eyes(41.7%)of the single group,whereas only 2 eyes (8.7%) in combined group,the difference between the two groups was significantly(P<0.05).In the early stage of postoperation,the IOP in two groups has no difference,three months later,the IOP in single group was lower than that of the combined group,the difference was significant (P<0.05).The percentage of functioning blebs in combined group was 87.5%,and that in the single group was 70.83%.Complications involving shallow anterior chamber,bleb leaking,persistant hypotony,macular edema was less in combined group than that in single group.Conclusions:Amniotic membrane transplation combined low dose mitomycin C can effectively control IOP and maintain the functional bleb,and has less complications,it is worthy of application in glaucoma surgical operation.更多还原