【摘要】 目的探讨电刺激小脑顶核(FNS)对帕金森患者的运动症状及抑郁症状的影响。方法将105例伴随抑郁症状的帕金森病(PD)患者随机分为FNS+美多巴组(药物+刺激组)、单纯刺激组(刺激组)、单纯美多巴组(药物组),每组35例。根据分组,对需要刺激的患者予以FNS治疗,每次通电30min,每日治疗1次,连续治疗30d。需要服药的患者仍按常规服用美多巴。所有患者治疗期间美多巴用量不变。于治疗前、后予以改良Webster评分及汉密尔顿抑郁分级量表(HAMD)评分。结果 FNS治疗后,药物+刺激组患者运动症状有所改善,抑郁症状有所减轻,Webster和HAMD评分均减少,其差异具有统计学意义(P<0.05);单纯刺激组运动症状改善不明显,但抑郁症状有所减轻,其差异具有统计学意义(P<0.05);单纯药物组则无明显改变。结论电刺激小脑顶核作为康复疗法,在改善帕金森病患者运动症状和抑郁症状方面均有疗效,是一种行之有效的疗法,适用于PD患者的康复治疗。更多还原

【Abstract】 Objective To study the therapeutic effects of cerebellar fastigial nucleus electrical stimulation(FNS)on motor and depression symptoms patients with Parkinson’s Disease(PD).Methods T105 idiopathic parkinson’s disease patients with depression were studied.All patients were divided randomly into FNS+ Madopar group,Madopar group and FNS group.Every group was 35 patients.According to different groups,some of these patients were treated with FNS,30 miniutes per time each day.The treatment could last as long as 30 days.Some of these patients took Modopar.During the period of research,Madopar dose has no change.Before and after FNS treatment,we evaluated the patients by use of the Webster Parkinson’s Disease Evaluation Form,Hamilton Depression Scale(HAMD).Results TAfter the treatment of FNS,motor and depression of the patients in FNS+ Madopar group were alleviated and scored significantly lower on Webster and HAMD(P<0.05);the motor symptoms of the patients in FNS group has no significant change,but the depression was improved effectively(P<0.05).The patients in Madopar group has no similar change.Conclusion TAs a rehabilitation treatment,FNS is efficient to relieve the motor and depression symptoms of PD.更多还原