【摘要】 目的探讨咪达唑仑与七氟烷在唇、腭裂患儿麻醉诱导插管时的相互作用。方法选择ASAⅠ级唇、腭裂患儿82例,年龄6个月-3岁,随机分为全凭七氟烷组(A组);咪达唑仑复合七氟烷组(B组)。以气管插管时有无体动反应为指标,采用序贯法分别测得两组气管插管时七氟烷的半数有效量(ED50),并比较两组对循环和呼吸的影响。结果全凭七氟烷组的ED50为4.2%,95%的可信区间为4.1%-4.3%;咪达唑仑复合七氟烷组的ED50为3.7%,95%的可信区间为3.6%-3.9%;咪达唑仑复合组在诱导期间对呼吸的影响更小。结论复合咪达唑仑可以降低七氟烷在小儿吸入诱导插管时的半数有效量(ED50),并减少了呼吸抑制。更多还原

【Abstract】 Objective To study the anesthetic interaction of midazolam with sevoflurane for trachea intubation in cleft lip and palate patients.Mathods Eighty-two cleft lip and palate patients (ASA I) who were 6 months to 3 years old were randomly divided into two groups.The patients in group A were given sevoflurane only,in group B midazolam plus sevoflurane. Movement of body in response to trachea intubation was measured to determine the value of sevoflurane ED50 in each group by up and down sequential allocation technique and to compare the effect on circulate and breath system.Results The value of sevoflurane ED50 was 4.2% in group A,3.7% in group B; The 95% confidence interval of sevoflurane in group A was 4.1%-4.3% and 3.6% -3.9% in group B. The effect of breath system in group B was less than that in group A.Conclusion Sevoflurane combined with midazolam reduces ED50 during trachea intubation in cleft lip and palate patients with less respiratory depression.更多还原