【摘要】 目的:探讨西酞普兰治疗广泛性焦虑症的疗效与安全性。方法:将80例广泛性焦虑症患者随机分为西酞普兰组(40例)和阿普唑仑组(40例),治疗前与治疗第1、2、4周末采用焦虑自评量表(SAS)、汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)评定疗效及副反应。结果:西酞普兰组与阿普唑仑组对广泛性焦虑症均有显著疗效。两组间差异无显著性。西酞普兰组不良反应明显小于阿普唑仑组。结论:西酞普兰治疗广泛性焦虑症安全有效,不良反应少,依从性好。更多还原

【Abstract】 Objective:To study the efficacy and safety of citalopram in the treatment of generalized anxiety disorder.Methods: 80 patients with generalized anxiety disorder were randomly assigned into a citalopram group(40 cases) and a alprazolam group(40 cases).Before treatment and at the end of the 1st,2nd and 4th week after treatment,self-rating Anxiety Scale(SAS),Hamilton Anxiety Scale(HAMA) and the side effects scale(TESS)were used to evaluate the efficacy and side effects.Results:Both citalopram and alprazolam had significant efficacy on generalized anxiety disorder group,but no significant difference was made between the two groups.The adverse reaction of citalopram group was significantly fewer than that of alprazolam group.Conclusion: Citalopram is a safe and effective treatment for generalized anxiety disorder,with fewer side effects and better compliance.更多还原