【摘要】 目的:探讨银屑病患者治疗前后血清IL-2、TNF-α和IFN-γ水平的变化及临床意义。方法:应用放射免疫分析和酶联免疫法对37例银屑病患者进行治疗前后血清IL-2、TNF-α和IFN-γ测定,并与35名正常健康人作比较。结果:在治疗前血清IL-2水平显著地低于正常人组(P<0.01),而血清TNF-α、IFN-γ水平则显著地低高于正常人组(P<0.01),经治疗后3个月与正常人组比较仍有显著性差异(P<0.05)。结论:IL-2、TNF-α和IFN-γ在银屑病的发生、发展过程中相互作用,观察其浓度的变化及探讨其发病机理,预防和指导用药均有重要的临床价值。更多还原

【Abstract】 Objective To study the significance of changes of serum IL-2,TNF-α and IFN-γ levels after treatment in patients with psoriasis.Methods Serum levels of IL-2,TNF-α(with RIA)and IFN-γ(with ELISA)were measured both before and after treatment in 37 patients with psoriasis and 35 controls.Results Before treatment,the serum IL-2 levels in patients were significantly lower than those in controls(P<0.01),while the serum TNF-α and IFN-γ levels were significantly higher(P<0.01).After treatment for 3 months,the levels though markedly corrected,were still significantly different from those in controls(P<0.05).Conclusion The levels of serum IL-2,TNF-α and IFN-γ increased significantly in patients with psoriasis especially in those advanced cases.更多还原