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转基因抗矮花叶玉米对大鼠部分亚慢性毒性指标的影响
Effects of Genetically Modified Anti-dwarf Mosaic Maize on Some Sub-chronic Toxicity of Rats
【摘要】 [目的]对转基因抗矮花叶玉米进行食用安全性评价。[方法]以SD大鼠为研究对象,选用离乳的大鼠80只,雌、雄各40只,按性别和体重随机分为4组,在日粮中添加中等剂量的转基因抗矮花叶玉米,进行90d的全食物饲喂,检测大鼠生长性能、尿液及脏器指数的变化。[结果]饲喂30%和50%转基因玉米日粮组的大鼠的各周累积体重和平均每周日采食量与饲喂传统玉米组相比没有显著差异;饲喂转基因玉米对大鼠的尿液参数没有显著影响,所有大鼠的尿比重均在正常的生理值范围内,平均为1.0000~1.1580g/ml;饲喂转基因玉米组大鼠的心脏、脑、脾脏、肝脏、肾脏、胸腺的相对重量与饲喂传统玉米组相比无显著差异。[结论]转基因抗矮花叶玉米与常规非转基因玉米具有相同的生物学营养等价性。
【Abstract】 [Objective] The study aimed to make the food safety evaluation on the genetically modified anti-dwarf mosaic maize.[Method] With SD rats as the experimental object of study,the chosen 80 weaning rats,40 for males and females resp.,were randomly divided into 4 groups according to the sex and their body weight,which were fed by the full of food for 90 d with their diets supplemented with the moderate doses of genetically modified anti-dwarf mosaic maize to detect the growth performance,urine and visceral organ index changes of rat.[Result] The weekly cumulative average weight and daily feed intake weekly of the rats fed by 30% and 50% of the genetically modified maize diet group had no significant difference compared with that fed by the conventional corn.Feeing the genetically modified maize on rats showed no significant effect on the urine parameters of the rats,the urine specific gravity of the rats were within the normal physiological values,with an average of 1.000 0-1.158 0 g/ml.The relative weight of the heart,brain,spleen,liver,kidney and thymus of rats fed by the genetically modified corn had no significant difference,compared with that fed by the conventional maize.[Conclusion] The genetically modified anti-dwarf mosaic maize and the conventional non-genetically modified corn has the same biology nutrition equivalence.
【Key words】 Genetically modified maize; Rats; Growth performance; Pathology index;
- 【文献出处】 安徽农业科学 ,Journal of Anhui Agricultural Sciences , 编辑部邮箱 ,2010年12期
- 【分类号】S865.12
- 【被引频次】10
- 【下载频次】112