【摘要】 目的研究人类白细胞抗原(human leukocyte antigen,HLA)HLA-DRB1等位基因多态性与急性淋巴细胞白血病(ALL)的相关性。方法采用Luminex流式技术-序列特异性寡核苷酸探针反向杂交(flow cytometry-sequencespecific oligonucleotide probe,FLOW-SSOP)方法对内蒙地区48例急性淋巴细胞白血病患者HLA-DRB1等位基因多态性进行分析,以北方地区健康群体资料作为正常对照。结果在急性淋巴细胞白血病中,DRB1*14XX等位基因频率较高,为5.352%;DRB1*13XX等位基因频率较低,为1.047%;白血病组和对照组比较DRB1*14XX等位基因频率高于对照组(P<0.05);DRB1*13XX等位基因频率低于对照组(4.428%,P<0.05);其它等位基因频率在两组之间差异无统计学意义。结论不同类型的白血病分别与不同型别的HLA基因有明显的相关性。更多还原

【Abstract】 Objective:To explore the correlation between the HLA-DRB1 alleles and susceptibility to acute lymphocyte leukemia in Inner Mongolin.Methods:HLA-DRB1 alleles polymorphism in ALL patient of 48 were examined with flow cytometry-sequence specific oligonucleotide probes(FlOW-SSOP) methods.2516 normal subjects in Northern China as control.Results:The frequencies of allele HLA-DRB1*14XX were increased(P<0.05);while the frequencies of allele HLA-DRB1*13XX were decreased in patients with leukemia(P<0.05).Conclusion:These results suggested that positive association may exist between certain HLA genes and leukemias.更多还原