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冠心病不稳定性心绞痛血瘀证与超敏c反应蛋白 载脂蛋白A1关系的临床探讨

Clinical Explore of Relationship Between High Sensitive C-reactive Protein(hs-CRP)and Apolipoprotein A1 Level of the Blood Stasis Syndrome in Unstable Angina Pectoris of Coronary Heart Disease(CHD)

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【作者】 其其格王伟毕力夫郭淑贞李赞华

【Author】 QI Qi-ge1,2,WANG Wei1,BI Li-fu2,GUO Shu-zhen1,LI Zan-hua1(1.Beijing University of Chinese Medicine,Beijing 100029,China;2.Inner Mongolia Medical College,Huhhot 010059,Inner Mongolia,China)

【机构】 北京中医药大学内蒙古医学院

【摘要】 目的:探讨冠心病不稳定性心绞痛血瘀证患者超敏c反应蛋白(Hs-CRP)、载脂蛋白A1水平及其临床意义。方法:31例冠心病不稳定性心绞痛血瘀证患者、20例冠心病不稳定性心绞痛气虚证患者和31例无冠心病对照组,分别测血浆Hs-CRP、载脂蛋白A1/B100、纤维蛋白原、脂蛋白a水平,并做单因素方差分析。结果:冠心病不稳定性心绞痛血瘀证组、气虚证组、无冠心病对照组3组间血浆Hs-CRP、载脂蛋白A1、A1/B100水平有显著性差异(P<0.05),且冠心病不稳定性心绞痛气虚证组Hs-CRP水平最高,其次为血瘀证组,无冠心病组最低;冠心病不稳定性心绞痛气虚证组载脂蛋白A1、A1/B100水平最低,其次为血瘀证组,无冠心病组最高。3组间纤维蛋白原、载脂蛋白B100、脂蛋白a差异无统计学意义(P>0.05)。结论:冠心病不稳定性心绞痛血瘀证和气虚证与载脂蛋白紊乱、炎症反应有相关性关系。

【Abstract】 Objective:To explore of the relationship between high sensitive C-reactive protein(hs-CRP)and apolipoprotein A1 level of the Blood Stasis Syndrome in unstable angina pectoris of Coronary Heart Disease(CHD)and the clinical value.Methods:31 patients of unstable angina pectoris CHD of BSS type,20 patients of unstable angina pectoris CHD of qi-deficiency type and 31 patients of non CHD(control),were detected the level of blood plasma hs-CRP,apolipoprotein A1/B100,fibrinogen,lipoprotein,and used the one-way analysis of variances.Results:There were significant differents among the blood plasma hs-CRP、apolipoprotein A1,A1/B100,in the patients of unstable angina pectoris CHD of BSS type,qi-deficiency type,non CHD(control)(P<0.05),and the hs-CRP level was the highest in the group of unstable angina pectoris CHD of qi-deficiency type,the next is the group of BSS type,then was the group of non CHD.The apolipoprotein A1,A1/B100 level was the lowest in the group of unstable angina pectoris CHD of qi-deficiency type,the next is the group of BSS type,and the highest was the group of non CHD.There was no statistics differents among the fibrinogen,apolipoprotein B100,lipoprotein in the three groups((P>0.05).Conclusion:The unstable angina pectoris CHD of BSS type are related with the disorder of polipoprotein and the inflammatory reaction.

【基金】 国家重点基础研究发展计划(973计划)资助项目(2003CB517105)
  • 【文献出处】 中华中医药学刊 ,Chinese Archives of Traditional Chinese Medicine , 编辑部邮箱 ,2009年07期
  • 【分类号】R541.4
  • 【被引频次】12
  • 【下载频次】310
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