Clinical Observation on the Treatment of Male Neoplastic Anemia with Yixuesheng Capsule(益血生胶囊) Combined with Recombination Human Erythropoietin

【摘要】 <正>Objective:To explore the efficacy and mechanism of Yixuesheng capsule（益血生胶囊,YXS） combined with recombination human erythropoietin（RHE） in treating male neoplastic anemia（NA）.Methods: Sixty-five patients were randomized into two groups,the 33 patients in the treated group treated with a combined therapy of YXS and RHE,and the 32 in the control group treated with RHE alone,all for 12 weeks.Related clinical indexes,including hemoglobin（Hgb）,red blood cell（RBC）,hematocrit（HMC）,testosterone（T）,estradiol （E₂） and prolactin（PRL）,were measured before and after treatment.Results:After treatment,Hgb in the treated group and the control group was 108±5 g/L and 104±8 g/L respectively,showing marked improvement as compared with that before treatment（P<0.01）,and the improvement in the former was more significant than that in the latter（P<0.05）.Further,the level of T was also increased in the treated group after treatment（P<0.05）, and showed a significant difference from that of the control group（P<0.05）.Conclusions:YXS capsule combined with RHE shows a better therapeutic effect in treating NA than that of RHE alone,and the effect might be through stimulation by YXS of erythropoiesis which could promote the secretion of testosterone.更多还原

【Abstract】 Objective:To explore the efficacy and mechanism of Yixuesheng capsule（益血生胶囊,YXS） combined with recombination human erythropoietin（RHE） in treating male neoplastic anemia（NA）.Methods: Sixty-five patients were randomized into two groups,the 33 patients in the treated group treated with a combined therapy of YXS and RHE,and the 32 in the control group treated with RHE alone,all for 12 weeks.Related clinical indexes,including hemoglobin（Hgb）,red blood cell（RBC）,hematocrit（HMC）,testosterone（T）,estradiol （E₂） and prolactin（PRL）,were measured before and after treatment.Results:After treatment,Hgb in the treated group and the control group was 108±5 g/L and 104±8 g/L respectively,showing marked improvement as compared with that before treatment（P<0.01）,and the improvement in the former was more significant than that in the latter（P<0.05）.Further,the level of T was also increased in the treated group after treatment（P<0.05）, and showed a significant difference from that of the control group（P<0.05）.Conclusions:YXS capsule combined with RHE shows a better therapeutic effect in treating NA than that of RHE alone,and the effect might be through stimulation by YXS of erythropoiesis which could promote the secretion of testosterone.更多还原