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链霉素对结核杆菌的药物敏感性试验

Study on the primary drug resistance against Streptomycin for tuberculosis

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【作者】 刘贤贵汪保国陈思东周勇周卫平

【Author】 LIU Xian-gui,WANG Bao-guo, CHEN Si-dong,et al.School of Disease Prevent and Control of Changan Hospital,Dongguan Guangdong,523843,China

【机构】 广东省东莞长安医院预防保健所广东药学院公共卫生学院广东药公共卫生学院广州白云区疾病预防控制中心学院

【摘要】 目的分析结核分支杆菌对链霉素药物的敏感性状况,为结核病的防治提供理论依据。方法将标本经抗酸染色确认后,采用绝对浓度法的间接法进行耐药性测定。结果60株结核杆菌标本直接涂片,经抗酸染色确认,阳性率为100%,进行链霉素的药物敏感性试验,共有59株发生耐药,总耐药率为98.3%(59/60)。结论结核分枝杆菌对链霉素的初始耐药率处于较高水平,必须进一步加强对耐药结核杆菌的监控。

【Abstract】 Objective To study on the situation and trend of Streptomycin resistance for tuberculosis and provide the basis for tuberculosis prevention and treatment. Methods The positive samples were inoculated into the modified Lowenstein-Jensen medium. The positive samples were subjected to susceptibility testing against Streptomycin using absolute concentration method. Results The positive sample rate of 100%. The prevalence rate of primary drug resistance was 98.3%(59/60). Conclusions The rate of primary drug against Rifampin still to be at a higher level. So superview to the resistance of tuberculosis should be further strengthened now.

【基金】 广东省医学科学技术研究基金(项目编号:A200539)
  • 【文献出处】 中国实用医药 ,China Practical Medicine , 编辑部邮箱 ,2009年12期
  • 【分类号】R446.5
  • 【被引频次】1
  • 【下载频次】119
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