【摘要】 目的:探讨抑郁发作患者血浆孤啡肽(OFQ)水平的变化,为抑郁发作的起病、诊断、治疗等寻找新的生物学指标。方法:筛选45例抑郁发作患者和31例正常人,应用放射免疫(RIA)法分别测定其血浆OFQ浓度,比较抑郁组与对照组血浆OFQ水平,抑郁组OFQ含量与各量表总分的相关性,分析相关的影响因素。结果:①抑郁组血浆OFQ水平显著高于对照组(t=4.65,P<0.01)。②抑郁组OFQ含量与HAMD、MADRS、HAMA总分均呈显著正相关。③血浆OFQ含量的影响因素主要有家人的关心、睡眠状况、家庭和睦、自杀观念或未遂史和总病程。结论:血浆OFQ水平的变化可能与抑郁发作的发病机制相关并反映疾病的严重程度。更多还原

【Abstract】 Objective:To investigate the changes of plasma orphanin FQ(OFQ)level in patients with bipolar and unipolar depression.Methods:45 patients with depression and 31 health adults were studied.The concentrations of plasma OFQ were measured by radioimmunoassay(RIA).Results:①Compared with the healthy controls,the level of plasma OFQ was significantly higher in patients with depression(t=4.65,P<0.01).②The plasma OFQ level was positively correlated to HAMD,MADRS and HAMA.③Many factors affected the level of plasma OFQ,including insomnia,family relationship,history of suicide,etc.Conclusion:The changes of plasma OFQ level may play a role in the pathogenesis of depression and reflect the severity of disease.更多还原