【摘要】 目的:考察注射用炎琥宁与头孢噻肟钠在0.9%氯化钠注射液中的配伍稳定性。方法:采用高效液相色谱法测定注射用炎琥宁与头孢噻肟钠配伍后在室温下8h内的含量变化,并观察和检测配伍液的外观及pH值变化。结果:配伍液pH值无明显变化,颜色随时间变化逐渐加深,头孢噻肟钠相对百分含量在6h后降至95%以下,3h后降解产物峰面积占总峰面积百分比超过1%。结论:注射用炎琥宁与头孢噻肟钠在0.9%氯化钠注射液中可配伍使用,但应在3h内用完。更多还原

【Abstract】 OBJECTIVE:To study the compatible stability of Potassium Sodium Dehydroandrographolide Succinate for Injection with Cefotaxime Injection in 0.9% sodium chloride injection.METHODS:The content of the mixture of Potassium Sodium Dehydroandrographolide Succinate for Injection and Cefotaxime Injection within 8 hours was determined by HPLC,and the appearance of the mixture was observed and its pH value was determined.RESULTS:No significant change was noted for the mixture in pH value,but its color deepened time-dependently.The relative content of Cefotaxime Sodium decreased to below 95% after 6 h,and the peak area of the degradation product accounted for over 1% of the total peak area after 3 h.CONCLUSION:The mixture of Potassium Sodium Dehydroandrographolide Succinate with Cefotaxime Sodium Injection is stable in 0.9% Sodium Chloride Injection within 3 hours.更多还原