【摘要】 目的检测血红蛋白H病患者体内血清转铁蛋白受体(sTfR)及血清铁蛋白(SF)的浓度,了解HbH病患者体内的铁负荷状况,并分成缺失型和非缺失型两组,通过对sTfR及其复合参数sTfR/1gSF进行分析比较,重点了解缺失型和非缺失型HbH病患者体内铁负荷状况。方法采用酶联免疫吸附反应(ELISA)分别检测26例缺失型(HbH)及24例非缺失型(HbH-CS)患者及30例健康对照者血浆中的sTfR及SF的浓度,通过计算分别得出两组的sTfR/1gSF值;以血清铁蛋白作为标准对sTfR/1gSF、sTfR这两个参数在诊断HbH病患者体内是否存在铁超负荷状况时的价值进行分析。结果在缺失型和非缺失型(HbH-CS)分组中,SF值的比较,两组值均高于对照组,且非缺失型增高较缺失型明显,有统计学意义:sTfR值缺失型和非缺失型两组值均低于对照组,有统计学意义,但两组间sTfR值比较无统计学意义;缺失型与非缺失型组的sTfR/1gSF均数与标准差经两样本t检验,差异有统计学意义(P<0.01),非缺失型组低于缺失型组。结论HbH病患者sTfR水平降低,结合SF结果联合判断,提示有铁超负荷的存在,非缺失型的患者较缺失型患者更易发生铁趋负荷。更多还原

【Abstract】 Objective To measure the levels of serum transferrin receptors(sTfR)in patients with hemoglobin H disease for investigation of iron metabolism(sideropenic or iron overload)which guide to proper modalities of treatment.In this study,we distributed 2 groups according to its types;deletion types of hemoglobin H disease(HbH)and non-deletion types of hemoglobin H disease(HbH-CS).Iron overload condition in HbH patients are analysed by comparing the parameters of sTfR and sTfR/lgSF.Methods Peripheral blood specimens were obtained from 26 cases of deletion types of hemoglobin H disease patients,24 cases of non-deletion types of hemoglobin H disease(HbH-CS)and 30 cases of normal cases for controls.The levels of sTfR and SF were examined by Enzyme-linked immunosorbent assay(ELISA).Results The levels of SF in both HbH patient group was higher than the control group(P<0.01),The levels of SF in HbH-CS patients has significantly higher than HbH patients(P<0.01).The levels of sTfR in both HbH patient group has significantly lower than the control group(P<0.01),but there was no statistical significance between two groups;The sTfR/1gSF value in HbH-CS patients has significantly lower than HbH patients(P<0.01).Conclusions The levels of sTfR in both HbH patient group was lower than the control group according to the value of SF,iron overload was found in both groups,in non-deletion types of hemoglobin H disease(HbH-CS)there was higher risk of iron overloads than HbH patients.更多还原