【摘要】 目的探讨代谢综合征(MS)的最主要组成成分。方法入选研究对象94例,以2005年国际糖尿病联盟(IDF)建议及中华医学会糖尿病学分会(CDS)建议MS标准(2006年中国成人血脂异常防治指南修订)作为诊断标准,比较MS与非MS两组患者年龄、收缩压、舒张压、空腹血糖、三酰甘油、高密度脂蛋白、低密度脂蛋白、腰围、体质量指数(BMI)、纤维蛋白原、高敏C反应蛋白(hsCRP)、白细胞的差别,用偏最小二乘判别分析(PLSDA)分析两种诊断标准中MS的最主要组成成分并比较两种诊断标准的异同。结果按IDF建议及CDS建议诊断的MS组患者年龄、腰围、BMI、收缩压、舒张压、三酰甘油、低密度脂蛋白胆固醇、空腹血糖、hsCRP、空腹胰岛素、胰岛素抵抗指数、纤维蛋白原高于非MS组。PLSDA得分图示MS组与非MS组可以明显分开。变量荷载图示腰围、BMI、收缩压、舒张压、年龄均是MS的主要组成成分,其中以肥胖指标最为重要。以CDS标准为标准对IDF标准进行预测评价,IDF诊断MS的灵敏度为100%,特异度为92.5%,判对率96.8%。结论肥胖、高血压、年老是IDF标准及CDS标准的3种重要组成成分,其中肥胖指标最为主要。更多还原

【Abstract】 Objective To explore the most important risk factors in metabolic syndrome(MS) components.Methods Ninety-four individuals were classified into MS and non-MS group according to the diagnostic criteria for MS proposed by Chinese Diabetes Society(CDS) revised in 2006 or International Diabetes Federal(IDF) in 2005.Age,waist circumference(WC),body mass index(BMI),fasting plasma glucose,lipid profile,blood pressure and blood cell counts in two groups were compared.Partial least squares discriminant analysis(PLSDA) was carried out to determine the most important components of MS.Results Patients with MS diagnosed by CDS or IDF criteria have significantly older age,higher BMI,WC,blood pressure,fasting plasma glucose,triglycerides,insulin levels,insulin resistance index,high sensitivity CRP and fibrinogen levels compared with non-MS group.PLSDA analysis shows WC,BMI,blood pressure and aging are most important components of MS.Conclusion Obesity,hypertension and aging are three most important components of MS with obesity is the utmost among them.更多还原