【摘要】 目的观察多西紫杉醇联合草酸铂和5-氟尿嘧啶治疗进展期胃癌的临床疗效及不良反应。方法32例进展期胃癌采用多西紫杉醇75 mg/m2,第1天静脉输注1 h;草酸铂100 mg/m2,第1天静脉输注3 h;醛氢叶酸0.2 g/m2,第1天静脉输注2 h;5-氟尿嘧啶2.4 g/m2用便携式微量输液泵持续静脉输注48 h,21天为1个周期。治疗2个周期后评价疗效和不良反应。结果32例患者均可评价,获得完全缓解(CR)1例、部分缓解(PR)13例、稳定(SD)11例、进展(PD)7例,总有效率(RR)为43.8%(14/32),中位疾病进展时间(TTP)6.5个月,中位生存期10.1个月。主要不良反应为骨髓抑制、腹泻、四肢末梢感觉异常,其中Ⅱ~Ⅲ度白细胞减少为65.7%(21/32),Ⅱ~Ⅲ度血小板减少为34.4%(11/32),Ⅰ~Ⅱ度神经毒性为56.3%(18/32),Ⅰ~Ⅱ度腹泻为18.8%(6/32)。结论多西紫杉醇联合草酸铂、5-氟尿嘧啶方案治疗进展期胃癌疗效肯定,且毒副反应可以耐受,患者临床受益。更多还原

【Abstract】 Objective To evaluate the efficacy and adverse reactions of combined regimen of docetaxel,5-fluorouracil(5-Fu) and oxaliplatin in the treatment of advanced gastric cancer.Methods 32 patients with advanced gastric cancer were treated with intravenous dripping of docetaxel 75 mg/m2 for 1 hr and oxaliplatin 100 mg/m2 3 h and intravenous dripping of CF 0.2 g/m2 for 2 h on day 1,coupled with continuous intravenous dripping of 5-Fu 2.4 g/m2 with a portable micro-infusion pump for 48 h.The regiment was repeated every 21 days and the clinical response and adverse reactions were recorded after two cycles.Results All the patients could be included for response rate and the overall response rate was 43.8%(14/32) with 1 case of complete response(CR) and 13 of partial response(PR),8 of steadiness(SD) and 2 of progressive disease(PD).Median time to progress(TTP) was 6.5 months,median survival time was 10.1 months.The main adverse reactions were myelosuppression,diarrhea and peripheral paresthesia on the extremities,including 65.7% grade Ⅱ and Ⅲ leucopenia(21/32) and 34.4% thrombocytopenia(11/32),56.1% grade I and Ⅱ neurological toxicity(18/32),and 18.8% grade I and Ⅱ diarrhea(6/32).Conclusion The efficacy of combined regimen of docetaxel,5-Fu and oxaliplatin is confirmed clinically for its better effects in the therapy of advanced gastric cancer,with tolerable toxicities and side effects.更多还原