【摘要】 [目的]研究氧化苦参碱、儿茶素、表儿茶素对鼻咽癌HNE-1及HNE-1(200)细胞的增殖抑制作用。[方法]以鼻咽癌HNE-1细胞株和放射照射诱导的HNE-1(200)耐药细胞株为研究对象,以维拉帕米为对照,采用MTT法测定氧化苦参碱、儿茶素、表儿茶素对两种细胞的增殖抑制率。[结果]氧化苦参碱对两种实验细胞均有抑制作用,且这种抑制作用呈浓度依赖性;氧化苦参碱的细胞抑制作用与维拉帕米相近。表儿茶素和儿茶素在本试验浓度下对两种细胞抑制作用不明显,抑制率均在20%以下。[结论]氧化苦参碱有明显的细胞抑制作用,表儿茶素和儿茶素未发现明显细胞毒作用。更多还原

【Abstract】 [Purpose] To investigate the effects of oxymatrine, catechin and epicatechinon on inhibiting cell proliferation in HNE-1 and HNE-1(200) cell line.[Methods] NPC HNE-1 cell line and multidrug resistant HNE-1(200) subline were used in the study.Inhibiting proliferation rate of oxymatrine, catechin and epicatechinon in two cell lines was detected by MTT.[Results] Oxymatrine inhibited cell proliferation in both cell lines with a concentrative dependent effect, it was similar to Verapamil.Epicatechin and catechin had no distinct inhibiting effect in both cell lines with the same experiment concentration.[Conclusions] Oxymatrine has markedly inhibiting effect on HNE-1 and HNE-1(200) cells growth, while Catechin and epicatechin do not have such inhibiting effect to these cell lines.更多还原