【摘要】 [目的]通过对黄石市某有色金属冶炼厂周边地区镉污染暴露人群血、尿等生物样品的检测,在血镉、尿镉中筛选出能敏感反映镉性肾早期损伤的暴露指标。[方法]现场采集污染区389人和对照区居民260人的血液和尿液,检测血镉、尿镉、尿肌酐、尿β2-MG及尿NAG酶等5项生物指标,以尿β2-MG及尿NAG酶两者之一超标为肾早期损伤阳性判断标准,通过ROC曲线下面积和Logistic回归模型的标准化偏回归系数来判断暴露指标血镉、尿镉的敏感性。[结果]649份样本中,血镉ROC曲线下面积(0.569,P﹤0.05)小于尿镉的ROC曲线下面积(0.725,P﹤0.05);相对肾早期损伤,尿镉的标准化偏回归系数(0.5036)大于血镉(-0.0212)。[结论]对于肾早期损伤的判断,暴露指标尿镉优于血镉。更多还原

【Abstract】 [Objective] To find the better indicator in pre-stage renal injury in blood cadmium and urinary cadmium by the survey of the persons who were exposed to cadmium pollution around one factory in Huangshi City. [Methods] Collected blood and urine samples from 649 participators, and calculated areas under the curves of blood cadmium and urine cadmium by SPSS software. Besides, compared standardized partial regression coefficient by Logistic Regression model. [Results] Among 649 samples, area under the ROC curves of blood cadmium (0.569) was not as large as that of urinary cadmium (0.725). And urine cadmium’s standardized partial regression coefficient (0.5036) was 23.75 times than blood cadmium’s (-0.021 2) in logistic regression model. [Conclusion] Urine cadmium is superior to blood cadmium in reflecting cadmium-reduced renal dysfunction.更多还原