【摘要】 分析麻保沙星(Marbofloxacin,MBF)在成年山羊体内的代谢动力学过程。山羊单剂量快速静注MBF 10 mg/kg,16 h内不同时间12次颈静脉采血,用高效液相色谱法测定血药浓度。结果表明,MBF在山羊体内的药物动力学配置符合无吸收因素二室开放模型。其药-时曲线最佳方程为:C=37.6434e-1.1106t+3.6700e-0.0891t;分布半衰期(t1/2α)为(0.6252±0.0299)h,消除相半衰期(t1/2β)为(7.7964±0.4069)h,药-时曲线下面积(AUC)为(75.1943±4.3712)μg/(mL.h),表观分布容积(Vd)为(1.4519±0.0904)L/kg,体清除率(CLB)为(0.1295±0.0119)L/(kg.h)。结果显示,MBF在山羊体内分布迅速而广泛,消除缓慢。更多还原

【Abstract】 Pharmacokinetic parameters of Marbofloxacin(MBF) in 6 goats were calculated.Goats were treated with a single dosage of MBF(10 mg/ kg) intravenously and rapidly,while the blood samples were collected from jugular vein within 16 hours after giving drug.The concentrations of MBF in serum were determined by high performance liquid chromatography(HPLC).The results showed that the two-compartment open model with first-order disabsorption factor adequately describes concentrations of MBF in serum disposition and the best concentration-time equations are : C = 37.6434e-1.1106t+3.6700e-0.0891t.The primary pharmacokinetic parameters of MBF are : t1/ 2α =(0.6252 ±0.0299) h,t1/ 2β=(7.7964 ±0.4069) h,AUC=(75.1943 ±4.3712)μg /(mL·h),Vd =(1.4519±0.0904) L/kg,CLB=(0.1295 ±0.0119) L/(kg·h-1).It will be seen that the distribution of MBF in vivo is rapid and abroad,and the elimination of MBF in vivo is slow.更多还原