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肝肾综合征的发病机制与肾血管调节
The pathogenesis and renal circulation regulation of hepatorenal syndrome
【摘要】 肝肾综合征系一种可逆性、"功能性"肾功能衰竭,常发生于进展期肝硬化和严重循环功能衰竭患者,其典型特征表现为内脏动脉血管扩张和心输出量减少,最终导致患者肾脏血管收缩。本文就肝肾综合征的发病机制和肾血流调节作一概述。
【Abstract】 Hepatorenal syndrome(HRS) is a reversible and "functional" renal failure that frequently occurs in patients with advanced cirrhosis and severe impairment in systemic circulatory function.The typical feature of the HRS is the splanchnic arterial vasodilation and the reduction of cardiac output.This results in activation of vasoconstrictors and suppression of vasodilators in the local renal circulation.The pathogenesis and renal circulation regulation of HRS are discussed in this review.
【关键词】 肝肾综合征;
发病机制;
循环功能;
肝硬化;
【Key words】 Hepatorenal syndrome; Pathogenesis; Circulatory function; Cirrhosis;
【Key words】 Hepatorenal syndrome; Pathogenesis; Circulatory function; Cirrhosis;
【基金】 河北省强势特色学科资助项目;河北省卫生厅科研基金资助课题(07009)
- 【文献出处】 胃肠病学和肝病学杂志 ,Chinese Journal of Gastroenterology and Hepatology , 编辑部邮箱 ,2009年04期
- 【分类号】R575.3;R692.5
- 【被引频次】16
- 【下载频次】514