【摘要】 目的观察理气宽胸活血法治疗心脏X综合征的临床疗效并探讨其作用机制。方法将55例心脏X综合征患者随机分为治疗组(28例)和对照组(27例)。对照组予常规西药治疗;治疗组在常规西药基础上加服理气宽胸活血方,疗程2周。观察患者治疗前后心绞痛症状、中医证候、心电图、平板运动试验指标及血内皮素(ET-1)、一氧化氮(NO)、高敏C反应蛋白(hs-CRP)等指标变化。结果治疗组心绞痛疗效、中医证候疗效总有效率分别为82.14%、85.71%,对照组分别为55.56%、55.56%,治疗组心绞痛疗效及中医证候疗效均优于对照组(P<0.05);治疗组心电图疗效总有效率为53.57%,对照组为48.15%,两组差异无统计学意义(P>0.05)。治疗后两组患者平板运动试验最大代谢当量均较治疗前显著提高(P<0.05),运动持续时间显著延长(P<0.05),运动后各导联诱发的ST段下移之和显著减小(P<0.05),治疗组均优于对照组(P<0.05);两组血ET-1、hs-CRP浓度均显著降低(P<0.05),NO浓度显著升高(P<0.05),治疗组均优于对照组(P<0.05)。结论理气宽胸活血法能显著改善心脏X综合征患者心绞痛症状、中医证候,改善患者运动耐量;其治疗心脏X综合征的机制,可能与其抑制血管壁的炎性反应、保护血管内皮功能有关。更多还原

【Abstract】 Objective To observe the clinical efficacy of qi-regulating,chest-relaxing and blood-activating therapy for cardiac syndrome X and its mechanisms.Methods Fifty -five subjects were randomized into two groups:control group in which 27 cases were treated with routine drugs and treatment group in which 28 cases were treated with the therapy above besides routine drugs,with a course of 2 weeks.The angina pectoris,Chinese medical syndrome,electrocardiogram,treadmill exercise test,and the levels of ET-1,NO and hs-CRP were observed.Results The effective rates for angina pectoris and Chinese medical syndromes were 82.14%and 85.71%in treatment group,and 55.56%and 55.56%in control group,with significant differences between the two groups(P<0.05).After treatments,the maximum metabolic equivalents of treadmill exercise test were obviously increased in both groups(P<0.05),exercise time prolonged and the sum of ST segments depression decreased(P<0.05),with better effects in treatment group than in control group(P<0.05);the levels of ET-1 and hs-CRP were strikingly drcreased(P<0.05),and the level of NO elevated(P<0. 05) in both groups,with better effects in treatment group than in control group(P<0.05).Conclusion Qi-regulating,chest-relaxing and blood-activating therapy is effective for cardiac syndrome X possibly by suppressing inflammation of vascular walls and protecting the functions of vascular endothelium.更多还原