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重复性经颅磁刺激对吗啡依赖小鼠条件性位置偏爱表达的影响

The Effect of rTMS on the CPP expression of morphine dependence mice

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【作者】 杨波周禹希严伟彭静胡丽娟

【Author】 YANG Bo~1 , ZHOU Yu-Xi~2, YAN Wei~3, PENG Jing~1, HU Li-Juan~4(1. Electronic Engineering College, Chengdu University of Information Technology, Chengdu 610225, China;2. School of Pharmacology, Chengdu medical college, Chengdu 610083, China;3. The fourth research lab, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China;4. Department of Immunology, College of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China)

【机构】 成都信息工程学院电子工程学院成都医学院药学院中国科学院光电技术研究所四室四川大学华西基础医学与法医学院免疫教研室

【摘要】 通过检测重复性经颅磁刺激(rTMS)对吗啡依赖小鼠条件性位置偏爱(CPP)表达的影响,探讨rTMS对吗啡依赖小鼠的治疗效应.结果显示rTMS治疗的前3d内,rTMS治疗组小鼠的CPP值显著低于CPP模型组(P<0.01),且维持在相对稳定的范围内.表明1HzrTMS能有效抑制吗啡依赖小鼠的CPP表达,可能成为戒毒治疗的新方法.

【Abstract】 To investigate the therapeutic effect of rTMS on morphine dependence mice,the effect of rTMS on CPP expression of morphine dependence mice was detected.The results showed the CPP expression of rTMS treatment group had a significant decrease (P<0.01) compared with CPP model group, and it kept stable in the first three days after rTMS treatment.The results implicated that 1 Hz rTMS treatment could effectively inhibit the CPP expression of morphine dependence mice,and might be a novel method for the treatment of drug addiction.

【基金】 成都信息工程学院引进人才项目(KYTZ20060906)
  • 【文献出处】 四川大学学报(自然科学版) ,Journal of Sichuan University(Natural Science Edition) , 编辑部邮箱 ,2009年06期
  • 【分类号】R749.6
  • 【被引频次】2
  • 【下载频次】60
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