【摘要】 目的了解泉州市2000-2007急性弛缓性麻痹(AFP)病例的发病情况、分布特征及AFP监测系统运转情况,为我市继续保持无脊髓灰质炎(脊灰)决策提供依据。方法采用回顾性调查方法,分析泉州市2002-2007年AFP病例个案调查表、随访表和实验室病毒学检测结果等资料。结果泉州市2002-2007年AFP病例监测系统共报告AFP病例183例,15岁以下儿童非脊灰AFP病例报告发病率为1.7/10万。AFP病例男女比为2.6∶1,以5岁小年龄组居多,全年各月分布无差异。报告AFP病例未完成OPV基础免疫及免疫史不详的病例分别占9.8%(18/183)和6.0%(11/183),其中181例为脊灰排除病例,2例为脊灰临床符合病例。AFP病例合格粪便标本采集率为96.2%(176/183),脊灰病毒分离率为4.0(7/176),其中6例为脊灰疫苗株,1例为脊灰疫苗高变异株。75d内随访及时率为99.4%(180/181)。结论2002-2007年泉州市无脊灰野病毒确诊病例,AFP病例监测系统各项指标均达到《全国急性弛缓性麻痹(AFP)病例监测方案》的要求,但适龄儿童的基础免疫工作仍需加强,还应加强临床医生的培训,提高AFP病例监测系统的工作质量。更多还原

【Abstract】 Objective To describe the characteristics of patients with acute flaccid paralysis (AFP) between 2002 and 2007, and to evaluate the performance of the AFP surveillance system using indicators recommended by the Health Ministry of P.R.C. Method Retrospective study, based on the case questionnaire, follow-up questionnaire and the results of polio virus isolation, was used to evaluate the occurrence of AFP between 2002-2007. Result 183 cases of AFP were reported between 2002-2007. The morbidity of AFP among children under 15 years old was 1 / 100,000. The sex ratio of male to female AFP patients was 2.6∶1, and most of the patients were under 5 years old. Seasonal variation in the disease occurrence was not seen. Among the 183 cases, 18(9.8%) subjects did not complete the routine immunization of oral polio vaccine (OPV) and 11 (6.0% ) subjects had unknown history of immunization. 181 cases were confirmed non-polio cases, 2 cases were clinical polio compatible cases. Adequate stool sample collection rate was 96.2% (176 / 183). Virus isolation rate was 4% (7 / 176 cases) in which vaccination strain was isolated in 6 cases and mutant strain was isolated in 1 case. 99.4% (180 / 181) received following up study within 75 days. Conclusion Infection by wild type poliovirus was not found in Quanzhou between 2002 and 2007. The AFP surveillance system is up to the national AFP monitoring standard. Strengthening of clinical training of medical doctors and children immunization program can improve the disease surveillance system.更多还原