【摘要】 目的检测多发性硬化(MS)患者血清尿酸(SUA)水平,并探讨其与病情活动性的关系。方法对MS患者采用大剂量甲泼尼龙进行冲击治疗后,利用酶定量分析法对54例MS患者及49例非炎症性神经系统疾病患者(NIND)SUA水平进行测定分析。结果MS患者中女性SUA水平明显低于男性患者(P<0.05),MS者SUA水平与年龄无明显关系(P>0.05)。MS患者急性期SUA水平明显低于缓解期及NIND对照组(P<0.05)。治疗后病灶显著减少,伴随SUA水平的回升。结论MS患者SUA水平较低,与性别密切相关,与年龄无关,SUA变化水平与MS患者病情变化相关,SUA可作为MS活动性的标志物之一。更多还原

【Abstract】 Objective To investigate the correlation of level of serum uric acid(SUA)in patients with multiple sclerosis with the acativity of the disase. Methods The MS patients were treated by high doses of intravenous methylprednisolone (IVMP),and a quantitative enzymatic assay according to the manufacture’s protocol was adopted for detection of levels of SUA in 54 patients with MS and 49 non-inflammatory neurological disease (NIND) were taken as controls. Results The level of SUA in patients with MS was significantly lower in comparison with NIND group and those in remission (P<0.05). The level of SUA of MS patients did not change obviously with age (P>0.05). After treatment,the number of focal zone decreased with the increase of SUA levels. Conclusion The levels of SUA in MS patients is low and it is related to the sex,and not related to the age. The lower level of SUA is an independent risk factor to multiple sclerosis. The level pf SUA can be potentially adopted as a marker of disease activity of MS and evaluation of therapeutic effect of IVMP treatment.更多还原