【摘要】 淋病奈瑟菌容易感染人,却难以感染所有常用实验动物,因此长期以来一直缺少合适的实验动物模型,严重限制了淋病奈瑟菌的研究进展。雌激素有一定的抗炎作用,利用雌激素处理小鼠,建立淋病奈瑟菌实验感染模型,有助于淋病奈瑟菌感染机制的研究、疫苗的开发和研制、以及抗淋病药物的筛选与评价。更多还原

【Abstract】 Recent studies of Neisseria gonococci infection in mouse have yielded important progress in the pathogenesis of Neisseria gonococci. Estrogens have an antiinflammatory effect. Estradiol treated mouse may be infected with Neisseria gonococci .This Neisseria gonococci infection mouse model treated with estradiol may serve as a useful tool for ascertaining gonococcal pathogenesis , evaluating potential gonococcal vaccine candidates , screening and estimating bactericide.更多还原