【摘要】 目的:探讨 Stevens-Johnson 综合征(SJS)及中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)的发生和发展规律、临床特点及治疗方法。方法:对2003—2007年我科收治的77例 SJS/TEN 患者的临床资料进行回顾性分析。结果:4例 SJS向 TEN 转化;卡马西平、解热镇痛类、抗生素为主要致敏药物;74例伴黏膜损害,肝功能损害43例,33例有皮肤触痛。77例患者均使用糖皮质激素治疗,13例重症患者联用静脉注射用人免疫球蛋白(IVIG)治疗;1例患者死亡。结论:SJS 和 TEN 是同一疾病系谱的不同发展阶段;早期足量使用糖皮质激素是治疗的主要手段,对于部分重症患者应联用 IVIG。更多还原

【Abstract】 Objective: To explore the regular rule of the development, the clinical characteristics and treatment regimens of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Methods: The clinical data of 77 inpatients with SJS/ TEN from 2003 to 2007 in our department were retrospectively analyzed. Results: Carbamazepine, antipyretic analgesics, and antibiotics were the predominant sensitizing agents. Among 77 patients with SIS/TEN, mucous membrane involvement was found in 74 cases, liver damage in 43 cases, tenderness in 33 cases. Four cases of SJS transformed to TEN. Systemic glucocorticosteroid was prescribed for all 77 cases. Intravenous immunoglobulin (IVIG) was administrated along with glucocortieosteroid in 13 cases. Only 1 patient died. Conclusions: SJS and TEN belong to a same disease-spectrum at different stages. The administration of systemic glucocorticosteroids with adequate doses at the early stage of SJS/TEN is the main therapy. IVIG should be given in some serious cases.更多还原