【摘要】 目的应用含司帕沙星化疗方案治疗耐多药肺结核,探讨耐多药结核病的治疗效果。方法选择39例均对INH、RFP、EMB、SM完全耐药的耐多药肺结核病例,采用司帕沙星[1](SPFX)、丙硫异烟胺、利福喷丁、丁胺卡那霉素强化治疗3个月,再用司帕沙星、丙硫异烟胺、利福喷丁三种药巩治疗9~15个月。疗程中每月进行痰结核菌检查,定期复查胸片、肝功、肾功。结果完成疗程的39例患者,用药后三个月内痰菌阴转率66.7%,完成巩固期后停药,随访两年未见一例复发。肝功异常反应率为2.6%。结论含司帕沙星化疗方案在耐多药肺结核治疗中疗效确切且副作用较少,值得临床推广。更多还原

【Abstract】 Objective To explore the therapeutic effect of multidrug-resistant tuberculosis(MDR-TB) cases with regimen contained with new tuberculosis resistant drugs.Methods 39 cases from 1998~2005,of INH/RFP/EMB/SM whole multidrug-resistant tuberculosis were treated,with sparfloxacin(SPFX)/protionamide/ rifapentine/amikacin for the first 3 months,then strengthened with sparfloxacin(SPFX)/protionamide/rifapentine for next 9 to 15 months.The patients were examined with sputum smear every month,and re-examined with chest X-ray,liver function,and kidney function periodically.Results All 39 patients completed their treatment,and the sputum negative conversion rate was 76.9% in the following 3 months.Completing the period of consolidation,the patients stopped their treatment.There were no recurrences among the patients in the next random-visited 2 years.The damage rate to liver function was 2.6%.Conclusion It is effective and reasonable to treating multidrug-resistant tuberculosis cases with the regimen contained with sparfloxacin,so that this regimen is worthy of recommending in clinical use.更多还原