【摘要】 目的探讨机械通气时机对重型颅脑损伤并中枢性呼吸衰竭患者呼吸功能恢复和预后的影响。方法48例重型颅脑损伤接受呼吸机通气治疗患者,比较在出现潜在的呼吸衰竭前和后,使用机械通气治疗前后血气分析指标、呼吸力学指标的变化及治疗后一个月的生存率及格拉斯哥预后评分(GOS)。结果两组患者血气分析指标和呼吸力学指标均有不同程度的改善。早期机械通气治疗组的机械通气时间(4.5±2.5)天,短于晚期治疗组(8.6±4.7)天,脱机率为70.8%,一个月后生存率为75%,GOS评分优于晚期治疗组。结论早期机械通气治疗可尽早改善重型颅脑损伤患者的低氧血症、降低病死率、改善预后。更多还原

【Abstract】 Objective To discuss the opportunity of mechanical ventilation (MV) in the treatment of respiratory failure with acute severe traumatic brain injury (TBI).Methods 48 patients with TBI were analyzed.Measures included the effects of early MV (before severe respiratory failure) versus late MV (after signs of severe respiratory failure) on blood-gas parameters,respiratory mechanics parameter,mortality and Glasgow Outcome Scale (GOS) after one month.Results In both groups,there were significant effects on improving the respiratory parameters,however more efficiency was observed in the early MV group (P<0.05) than the late. The average GOS and the mortality were better in the early MV group than that in the late MV group.Conclusion The early mechanical ventilation can significantly correct hypoxemia,decrease the mortality and improve outcome in severe traumatic brain injury patients.更多还原