【摘要】 目的观察活血Ⅰ号胶囊对2级高血压病血栓前状态的影响。方法152例2级高血压病患者随机分为左旋氨氯地平组、阿司匹林组、活血Ⅰ号组,分别予以口服左旋氨氯地平片、左旋氨氯地平片+肠溶阿司匹林片、左旋氨氯地平+活血Ⅰ号胶囊8周,观察治疗前后血压、一氧化氮、血管性假血友病因子、活化血小板颗粒膜蛋白及纤维蛋白原水平的变化。结果2级高血压病患者治疗前一氧化氮水平较健康成人明显下降(P<0.05),而血管性假血友病因子、活化血小板颗粒膜蛋白和纤维蛋白原水平均明显升高(P均<0.05);经治疗后,三组患者血浆一氧化氮水平均较治疗前升高(P<0.05),且活血Ⅰ号组升高最为明显(P<0.05),血管性假血友病因子、活化血小板颗粒膜蛋白和纤维蛋白原水平均较治疗前降低(P<0.05),其中血管性假血友病因子、活化血小板颗粒膜蛋白水平在左旋氨氯地平组与阿司匹林组之间差异无显著性(P>0.05),但活血Ⅰ号组较左旋氨氯地平组和阿司匹林组更低(P<0.05);阿司匹林组与活血Ⅰ号组中纤维蛋白原水平均明显低于左旋氨氯地平组(P<0.05),但活血Ⅰ号组更低(P<0.05)。结论活血Ⅰ号胶囊和氨氯地平通过保护血管内皮、稳定血小板功能治疗高血压血栓前状态。更多还原

【Abstract】 Aim To observe the effect of Huoxueyihao capsule combined with Levamlodipine on pre-thrombus state of hypertension 2.Methods 152 patients with hypertension 2 were divided into Levamlodipine group,aspirin group and huoxueyihao group,and treated by Levamlodipine Besylate tablet,Levamlodipine Besylate tablet and aspirin enteric-coated tablet,Levamlodipine Besylate tablet and Huoxueyihao capsule for 8 weeks respectively.The levels of blood pressure,nitric oxide(NO),von willebrand factor(vWF),granule membrane protein-140(GMP-140),plasma fibrinogen(Fg)were observed before and after treatment.Results Contrast in the health group,the levels of NO in patients were remarkably decreased(P<0.05),but the levels of vWF,GMP-140 and Fg were markedly increased(P<0.05).The levels of NO in the treated patients were all higher than those of before treatment(P<0.05),and the levels of Huoxueyihao group rise obviously(P<0.05).The levels of vWF,GMP-140,Fg all decreased after treatment(P<0.05),and those in Huoxueyihao group decreased especially(P<0.05).Conclusion Huoxueyihao capsule combined with Levamlodipine could be used in treating pre-thrombus state of hypertension 2 through protecting vascular endothelium and stabilizing platelet function.更多还原