【摘要】 目的:观察长效核黄素治疗复发性口腔溃疡的效果及对血清白细胞介素-2(IL-2)水平的影响。方法:408例轻型复发性口腔溃疡患者随机分为两组,对照组采用常规治疗,核黄素治疗组在常规治疗基础上一次性肌肉注射长效核黄素150 mg,每周1次,共用3个周期,比较两组总有效率及治疗前、后IL-2水平。结果:治疗后核黄素治疗组总有效率(95.1%)明显高于对照组(88.2%)(P<0.05);3个月后随访,核黄素治疗组复发率(11.2%)明显低于对照组(47.3%)(P<0.01);核黄素治疗组治疗后IL-2水平[(4.26±1.38)]U/mL较治疗前[(1.78±0.95)]U/mL及对照组[(2.39±0.71)]U/mL明显升高(P<0.05～0.01)。两组均未见明显不良反应。结论:长效核黄素治疗复发性口腔溃疡,疗效确切,复发率降低,未见明显毒副作用,值得临床推广。更多还原

【Abstract】 Objective: To study the curative effect and influence of serum IL-2 using riboflavine laurate on patients with recurrent oral ulcers.Methods: 408 cases of mild recurrent oral ulcers were randomly divided into two groups: The patients in experiment group were treated with riboflavine laurate 150 mg one time a week,last three period and routine treatment,while the patients in contorl group received only routine treatment.Total effective rate and the level of IL-2 before and after treatment in two groups were contrasted.Results:Total effective rate in treatment group was higher than that of control group(95.1% vs 88.2%,P<0.05);the rate of recurrence in treatment group was lower than that of control group(11.2% vs 47.3%,P<0.01);the level of IL-2 in treatment group after therapy(4.26±1.38)U/mL was higher than that of before therapy in treatment group(1.78±0.95)U/mL,and in control group(2.39±0.71)U/mL(P<0.05～0.01).No adverse effects were found in both groups.Conclusion:Riboflavine laurate has definitely curative effect on treating recurrent oral ulcers and lower recurrence rate,which is worth spreading.更多还原