【摘要】 叉状头/翅膀状螺旋转录因子(FOXP3)作为CD4+CD25+调节T(Treg)细胞表面的特征性标志,是Treg细胞发育和功能维持的关键因素,在维持机体免疫耐受和免疫应答稳态方面具有非常重要的作用。FOXP3基因突变可引发多种自身免疫性疾病,目前研究发现,FOXP3基因表达异常在自身免疫性甲状腺疾病的发病中发挥重要作用。更多还原

【Abstract】 As the characteristic surface marker of CD4 +CD25 + regulatory T cell,FOXP3 is a critical determinant of T regulatory cell’s development and function,and plays critical role in containing immune tolerance,immune response,and homeostasis.Mutations in the FOXP3 gene may cause many autoimmune diseases.Recent researches have shown that the abnormal expression of FOXP3 gene may play an important role in in the pathogenesis of autoimmune thyroid diseases.更多还原