【摘要】 目的研究存活素(survivin)和COX-2在骨巨细胞瘤中的表达及其意义,探讨影响骨巨细胞瘤预后的因素。方法采用免疫组化技术检测survivin和COX-2在39例骨巨细胞瘤和4例正常骨组织中的表达,结合临床、病理资料进行分析。结果survivin和COX-2在骨巨细胞瘤中的表达均明显高于正常骨组织(P<0.01),且分别与Jaffe病理分级存在正相关(P<0.01)。两者表达具有中度的一致性。在性别、年龄、手术方式之间无显著性差异(P>0.05)。Logistic回归分析显示瘤段截除加植骨术明显降低骨巨细胞瘤复发率,survivin、COX-2都不是预后的一个独立危险因素。结论Survivin和COX-2可能参与了骨巨细胞瘤的发生发展,但不能反映其预后。更多还原

【Abstract】 Objective To investigate the expression of survivin and COX-2 in giant cell tumor of bone(GCT) and explore the prognostic factors for GCT.Methods The expressions of survivin and COX-2 in 39 GCT tissues of three Jaffe grades and 4 normal bone tissues were detected by immunohistochemical staining, and the data were analyzed in relation to the clinicopathological features of the patients.Results The expressions of survivin and COX-2 were significantly higher in the GCT tissues than in normal bone tissues(P<0.01).A positive correlation was found between survivin and COX-2 expressions and the pathological grade(P<0.01), but their expressions were not correlated to the patients’ gender, age or surgical approaches(P>0.05).An obviously lowered recurrence rate was observed in patients with resection of the bone segment compromised by the tumor and subsequent bone grafting.Survivin and COX-2 were not independent risk factors of the prognosis of GCT.Conclusion Survivin and COX-2 expressions may participate in the pathogenesis and development of GCT, but is not indicative of the prognosis.更多还原