【摘要】 神经素是一个由33个氨基酸组成的神经肽,在不同物种中都有较高的保守性,在脑、内分泌组织、神经分泌组织和神经组织中特异表达。SN的前体蛋白是成熟的神经递质,被命名为Secretogranin Ⅱ(SgⅡ),属于嗜铬类蛋白家族。SN前体mRNA的表达水平很大程度上由细胞的去极化所调节,也可作为长期和瞬时神经活性变化的有用标记。在病理生理条件下,尤其是在细胞缺氧时,SN可以在非内分泌组织中表达。SN可特异、高效地吸引单核细胞,嗜曙红细胞形成浓度梯度,并且有促进血管生长的作用。因此,SN可介导神经性炎症反应,并且在由缺氧导致的局部缺血的症状中,SN可能与神经血管生成有关。更多还原

【Abstract】 Secretoneurin (SN) is a neuropeptide, which is comprised by 33 amino acids. SN is highly conserved between different species especially and specifically expressed in brain, endocrine, neuroendocrine and neuronal tissues. The precursor protein of SN is a neurotransmitter, which is named secretogranin Ⅱ, belongs to chromogranin family. The expression level of ProSN mRNA is significantly regulated by cell depolarization, could be used as a marker for both rapid and long-lasting changes in neuronal activity. Under pathophysiological conditions, especially in cellular hypoxia condition, SN could be expressed in non-endocrine tissues. SN could specifically attract the monocytes, eosinophils to form a concentration gradient and play a role as an angiogenic cytokine. Thus, SN could mediate the neurogenic inflammation and might have functions in neo-vascularisation in ischemic diseases (driven by hypoxia).更多还原