【摘要】 目的研究糖尿病对老年颈动脉硬化斑块发生的作用。方法随机抽取2005年10月至2008年2月住院老年患者1 298例,其中糖尿病617例,无糖尿病681例。记录患者一般资料,检测血糖、血尿酸、血脂,进行螺旋CT脑血管成像或数字减影CT全脑血管造影检查,并进行单因素和多因素分析。结果高血糖(χ2=8.04,P<0.01)、高血压病与颈动脉硬化斑块的发生显著相关(χ2=12.14,P<0.01)。高胆固醇(χ2=6.35,P<0.05)、低密度脂蛋白升高(χ2=5.81,P<0.05)与颈动脉硬化斑块的发生有关。在排除了高密度脂蛋白降低和三酰甘油升高因素后,高血压病(OR=2.61,95%CI=1.13~3.66)、高血糖(OR=2.50,95%CI=1.20~2.93)、高尿酸(OR=32.23,95%CI=1.19~3.31)与颈动脉硬化发生相关。糖尿病与颈动脉硬化斑块(OR=2.21,95%CI=1.13~3.46)发生相对危险度最高。结论糖尿病可能促进老年患者颈动脉硬化斑块的发生。更多还原

【Abstract】 Objective To study the association between diabetes mellitus and carotid plaques in older people.Methods Cluster random sampling methods were used in the investigation from Feb 2005 to oct 2008.Totally 1719 participants grouped as diabetes mellitus group(n=827) and control group(n=892) according to the results of the level of blood uric acid.All participants were screened with the CTA or DSA.Fasting blood glucose,serum uric acid and serum lipid(cholesterol,triglyceride) were analyzed by automatic biochemical analyzer.Results Hypertension(χ2=12.14,P<0.01),hyperglycemia(χ2=8.04,P<0.01),high cholesterol(χ2=6.35,P<0.05),Low density lipoprotein cholesterol(χ2=5.81,P<0.05)had association with carotid Plaque.Among diabetes mellitus,hypertension(OR=2.61,95%CI=1.13~3.66),hyperglycemia(OR=2.50,95%CI=1.20~2.93) appear to be more related to carotid plaque.Conclusion Diabetes mellitus accelerate carotid plaque in older people.更多还原