【摘要】 [目的]测定大豆苷元在各种溶剂中的平衡溶解度以及在正辛醇-水和正辛醇-缓冲液体系中的表观油水分配系数。[方法]采用HPLC法测定大豆苷元的浓度,采用摇瓶法测定大豆苷元的表观油水分配系数。[结果]25℃大豆苷元在水中的平衡溶解度为0.89mg/L。在碱性磷酸盐缓冲液中的平衡溶解度较酸性磷酸盐缓冲液中高;大豆苷元的表观油水分配系数Papp为191.3(1gPapp=2.28)。[结论]大豆苷元的水溶性较差,提高其口服制剂的溶出度有利于提高其生物利用度。更多还原

【Abstract】 [Objective] The study aims to determine the equilibrium solubility of Daidzein in various solvents and its apparent oil/water partition coefficients for the n-octanol-water/ buffer solution systems.[Method] The concentration of daidzein is determined by HPLC,apparent oil/water partition coefficient is determined by shaking flask method.[Result] The equilibrium solubility of daidzein in water is 0.89 mg/ L at 25 ℃ and higher in alkaline phosphate buffer than in others.Papp of Daidzein is 191.3(1gPapp=2.28).[Conclusion] Water solubility of Daidzein is bad,increasing the dissolution rate of Daidzein may have the possibility to enhance its bioavailability.更多还原